Decellularization as a method to reduce calcification in bovine pericardium bioprosthetic valves
نویسندگان
چکیده
منابع مشابه
Decellularization as an anticalcification method in stentless bovine pericardium valve prosthesis: a study in sheep.
OBJECTIVE The objective was to analyze the decellularization process with SDS in glutaraldehyde-preserved bovine pericardium as an anticalcification method in a circulatory sheep model. METHODS The valved tubs were implanted in pulmonary artery position in sheep by 180 days. The animals were divided in two groups of 8 animals: control group--glutaraldehyde-preserved bovine pericardium and the...
متن کاملThe Immune Responses and Calcification of Bioprostheses in the α1,3-Galactosyltransferase Knockout Mouse.
BACKGROUND The study aim was to evaluate the immune reaction, difference of degenerative calcification, and anti-calcification effect of decellularization with or without α-galactosidase in bovine pericardium and porcine heart valves, using an α1,3-galactosyltransferase (α-Gal) knockout (KO) mouse model. METHODS In order to elucidate the anti-calcification effect of decellularization with or ...
متن کاملAlkaline phosphatase activity of glutaraldehyde-treated bovine pericardium used in bioprosthetic cardiac valves.
Bioprosthetic valves fail frequently because of pathological mineralization, a process that begins in cell remnants of the glutaraldehyde (GLUT) fixed tissue. Other pathological cardiovascular calcification and physiological mineralization in skeletal/dental tissues are both largely initiated in cell-derived membranous structures (often called "matrix vesicles"), and the enzyme alkaline phospha...
متن کاملPrevention of calcification in bioprosthetic heart valves: challenges and perspectives.
Surgical replacement with artificial devices has revolutionised the care of patients with severe valvular diseases. Mechanical valves are very durable, but require long-term anticoagulation. Bioprosthetic heart valves (BHVs), devices manufactured from glutaraldehyde-fixed animal tissues, do not need long-term anticoagulation, but their long-term durability is limited to 15 - 20 years, mainly be...
متن کاملRGD-modified acellular bovine pericardium as a bioprosthetic scaffold for tissue engineering.
Acellular biological tissues, including bovine pericardia (BP), have been proposed as natural biomaterials for tissue engineering. However, small pore size, low porosity and lack of extra cellular matrix (ECM) after native cell extraction directly restrict the seed cell adhesion, migration and proliferation and which is a vital problem for ABP's application in the tissue engineered heart valve ...
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ژورنال
عنوان ژورنال: Interactive CardioVascular and Thoracic Surgery
سال: 2019
ISSN: 1569-9285
DOI: 10.1093/icvts/ivz041